von Geldern, Thomas: search on Z-Library

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1

Immune Mediated Diseases and Immune Modulation in the Neurocritical Care Unit

Gloria von Geldern, Thomas McPharlin, Kyra Becker

Journal:

Neurotherapeutics

Year:

2012

Language:

english

File:

PDF, 467 KB

english, 2012

2

Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: in vitro studies

WU-WONG, J. Ruth, DIXON, Douglas B., CHIOU, William J., SORENSEN, Brian K., LIU, Gang, JAE, H.-S., TASKER, Andrew, GELDERN, Thomas W. Von, WINN, Martin, OPGENORTH, Terry J.

Journal:

Clinical Science

Year:

2002

Language:

english

File:

PDF, 120 KB

english, 2002

3

Nucleophilic substitution with inversion of configuration at the nucleophile

Heathcock, Clayton H., Von Geldern, Thomas W., Lebrilla, Carlito B., Maier, Wilhelm F.

Journal:

Journal of Organic Chemistry

Year:

1985

Language:

english

File:

PDF, 635 KB

english, 1985

4

Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: ex vivo and in vivo studies

WESSALE, Jerry L., ADLER, Andrew L., NOVOSAD, Eugene I., CALZADILLA, Samuel V., DAYTON, Brian D., MARSH, Kennan C., WINN, Martin, JAE, Hwan-Soo, GELDERN, Thomas W.von, OPGENORTH, Terry J., WU-WONG, J.

Journal:

Clinical Science

Year:

2002

Language:

english

File:

PDF, 164 KB

english, 2002

5

Analogues of Fenarimol Are Potent Inhibitors of Trypanosoma cruzi and Are Efficacious in a Murine Model of Chagas Disease

Keenan, Martine, Abbott, Michael J., Alexander, Paul W., Armstrong, Tanya, Best, Wayne M., Berven, Bradley, Botero, Adriana, Chaplin, Jason H., Charman, Susan A., Chatelain, Eric, von Geldern, Thomas

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 522 KB

english, 2012

6

Novel p -Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intracellular Adhesion Molecule-1 Interaction. 2. Mechanism of Inhibition and Structure-Based Improvement of Pharmaceutical Properties

Liu, Gang, Huth, Jeffrey R., Olejniczak, Edward T., Mendoza, Renaldo, DeVries, Peter, Leitza, Sandra, Reilly, Edward B., Okasinski, Gregory F., Fesik, Stephen W., von Geldern, Thomas W.

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 440 KB

english, 2001

7

Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity

von Geldern, Thomas W., Morton, Howard E., Clark, Rick F., Brown, Brian S., Johnston, Kelly L., Ford, Louise, Specht, Sabine, Carr, Robert A., Stolarik, Deanne F., Ma, Junli, Rieser, Matthew J., Strue

Journal:

PLoS Neglected Tropical Diseases

Year:

2019

Language:

english

File:

PDF, 2.11 MB

english, 2019

8

Potent and Selective Non-Benzodioxole-Containing Endothelin-A Receptor Antagonists

Tasker, Andrew S., Sorensen, Bryan K., Jae, Hwan-Soo, Winn, Martin, von Geldern, Thomas W., Dixon, Douglas B., Chiou, William J., Dayton, Brian D., Calzadila, Samuel, Hernandez, Lisa, Marsh, Kennan C.

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 282 KB

english, 1997

9

Studies directed toward the total synthesis of securinega alkaloids

Heathcock, Clayton H., Jennings, Rex A., Von Geldern, Thomas W.

Journal:

Journal of Organic Chemistry

Year:

1983

Language:

english

File:

PDF, 537 KB

english, 1983

10

Amino-substituted heterocycles as isosteres of trans-cinnamides: design and synthesis of heterocyclic biaryl sulfides as potent antagonists of LFA-1/ICAM-1 binding

Gary T. Wang, Sheldon Wang, Robert Gentles, Thomas Sowin, Sandra Leitza, Edward B. Reilly, Thomas W. von Geldern

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 317 KB

english, 2005

11

Discovery of Potent Antagonists of Leukocyte Function-Associated Antigen-1/Intercellular Adhesion Molecule-1 Interaction. 3. Amide (C-Ring) Structure−Activity Relationship and Improvement of Overall Properties of Arylthio Cinnamides

Pei, Zhonghua, Xin, Zhili, Liu, Gang, Li, Yihong, Reilly, Edward B., Lubbers, Nathan L., Huth, Jeffery R., Link, James T., von Geldern, Thomas W., Cox, Bryan F., Leitza, Sandra, Gao, Yi, Marsh, Kennan

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 543 KB

english, 2001

12

Liver-Selective Glucocorticoid Antagonists: A Novel Treatment for Type 2 Diabetes.

von Geldern, Thomas W., Tu, Noah, Kym, Philip R., Link, James T., Jae, Hwan-Soo, Lai, Chunqiu, Apelqvist, Theresa, Rhonnstad, Patrik, Hagberg, Lars, Koehler, Konrad, Grynfarb, Marlena, Goos-Nilsson, A

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 24 KB

english, 2005

13

Synthesis and biological evaluation of novel, selective, nonsteroidal glucocorticoid receptor antagonists

Irini Akritopoulou-Zanze, Jyoti R Patel, Kresna Hartandi, Jehrod Brenneman, Martin Winn, John K Pratt, Marlene Grynfarb, Annika Goos-Nisson, Thomas W von Geldern, Philip R Kym

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 279 KB

english, 2004

14

Stimulation of atrial natriuretic peptide receptor/guanylyl cyclase- A signaling pathway antagonizes the activation of protein kinase C-α in murine Leydig cells

Ravindra Kumar, Thomas W von Geldern, Roberto A Calle, Kailash N Pandey

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

1997

Language:

english

File:

PDF, 226 KB

english, 1997

15

Synthesis, activity, metabolic stability, and pharmacokinetics of glucocorticoid receptor modulator–statin hybrids

J.T Link, Bryan K Sorensen, Chunqiu Lai, Jiahong Wang, Steven Fung, Daisy Deng, Maurice Emery, Sherry Carroll, Marlena Grynfarb, Annika Goos-Nilsson, Thomas von Geldern

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 302 KB

english, 2004

16

Pyrrolidine-3-carboxylic Acids as Endothelin Antagonists. 3. Discovery of a Potent, 2-Nonaryl, Highly Selective ET A Antagonist (A-216546)

Liu, Gang, Henry,, Kenneth J., Szczepankiewicz, Bruce G., Winn, Martin, Kozmina, Natasha S., Boyd, Steven A., Wasicak, James, von Geldern, Thomas W., Wu-Wong, Jinshyun R., Chiou, William J., Dixon, Do

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 253 KB

english, 1998

17

Encyclopedia of Reagents for Organic Synthesis || Disiamylborane

von Geldern, Thomas W.

Year:

2001

Language:

english

File:

PDF, 152 KB

english, 2001

18

Azole Endothelin Antagonists. 3. Using Δ log P as a Tool To Improve Absorption

von Geldern, Thomas W., Hoffman, Daniel J., Kester, Jeffrey A., Nellans, Hugh N., Dayton, Brian D., Calzadilla, Samuel V., Marsh, Kennan C., Hernandez, Lisa, Chiou, William, Dixon, Douglas B., Wu-Wong

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 355 KB

english, 1996

19

Cerebrospinal fluid JC virus antibody index for diagnosis of natalizumab-associated progressive multifocal leukoencephalopathy

Warnke, Clemens, von Geldern, Gloria, Markwerth, Philipp, Dehmel, Thomas, Hoepner, Robert, Gold, Ralf, Pawlita, Michael, Kümpfel, Tania, Mäurer, Mathias, Stangel, Martin, Wegner, Florian, Hohlfeld, Re

Journal:

Annals of Neurology

Year:

2014

Language:

english

File:

PDF, 296 KB

english, 2014

20

The effects of diminishing albumin binding to some Endothelin receptor antagonists

Bruce G. Szczepankiewicz, Radhika B. Bal, Thomas W. von Geldern, Jinshyun R. Wu-Wong, William J. Chiou, Douglas B. Dixon, Terry J. Opgenorth, Daniel J. Hoffman, Anthony J. Borre, Kennan C. Marsh, Bach

Journal:

Year:

1998

Language:

english

File:

PDF, 602 KB

english, 1998

21

2,4-Diarylpyrrolidine-3-carboxylic AcidsPotent ET A Selective Endothelin Receptor Antagonists. 1. Discovery of A-127722

Winn, Martin, von Geldern, Thomas W., Opgenorth, Terry J., Jae, Hwan-Soo, Tasker, Andrew S., Boyd, Steven A., Kester, Jeffrey A., Mantei, Robert A., Bal, Radhika, Sorensen, Bryan K., Wu-Wong, Jinshyun

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 402 KB

english, 1996

22

HPLC and PDMS analysis of cleavage products aid in the design of small, stable ANP analogues

EDWARD M. DEVINE JR., ALEXANDER M. BUKO, STEVEN P. CEPA, STEVEN K. DAVIDSEN, WILLIAM H. HOLLEMAN, CAROL A. MARSELLE, TERRY J. OPGENORTH, TODD W. ROCKWAY, THOMAS W. VON GELDERN

Journal:

Chemical Biology & Drug Design

Year:

1992

Language:

english

File:

PDF, 501 KB

english, 1992

23

A ring-reversed analog of atrial natriuretic peptide retains receptor binding, guanylate cyclase stimulation

Thomas W. von Geldern, Gerald P. Budzik, Terry P. Dillon

Journal:

Biochemical and Biophysical Research Communications

Year:

1992

Language:

english

File:

PDF, 362 KB

english, 1992

24

Liver-selective glucocorticoid receptor antagonism decreases glucose production and increases glucose disposal, ameliorating insulin resistance

Bradley Zinker, Amanda Mika, Phong Nguyen, Denise Wilcox, Lars Öhman, Thomas W. von Geldern, Terry Opgenorth, Peer Jacobson

Journal:

Year:

2007

Language:

english

File:

PDF, 287 KB

english, 2007

25

Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit

Bradley J. Backes, Kenton Longenecker, Gregory L. Hamilton, Kent Stewart, Chunqiu Lai, Hana Kopecka, Thomas W. von Geldern, David J. Madar, Zhonghua Pei, Thomas H. Lubben, Bradley A. Zinker, Zhenping

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 409 KB

english, 2007

26

Endothelins and endothelin receptor antagonists: Binding to plasma proteins

Jinshyun R. Wu-Wong, William J. Chiou, Daniel J. Huffman, Martin Winn, Thomas W. von Geldern, Terry J. Opgenorth

Journal:

Year:

1996

Language:

english

File:

PDF, 709 KB

english, 1996

27

New Antimitotic Agents with Activity in Multi-Drug-Resistant Cell Lines and in Vivo Efficacy in Murine Tumor Models

Szczepankiewicz, Bruce G., Liu, Gang, Jae, Hwan-Soo, Tasker, Andrew S., Gunawardana, Indrani W., von Geldern, Thomas W., Gwaltney, Stephen L., Wu-Wong, J. Ruth, Gehrke, Laura, Chiou, William J., Credo

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 224 KB

english, 2001

28

Azole Endothelin Antagonists. 2. Structure−Activity Studies

von Geldern, Thomas W., Kester, Jeffrey A., Bal, Radhika, Wu-Wong, Jinshyun R., Chiou, William, Dixon, Douglas B., Opgenorth, Terry J.

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 380 KB

english, 1996

29

An Evaluation of a C-Glucuronide as a Liver Targeting Group: Conjugate of a Glucocorticoid Antagonist.

Bryan K. Sorensen, J. T. Link, Thomas von Geldern, Maurice Emery, Jiahong Wang, Bach Hickman, Marlena Grynfard, Annika Goos-Nilsson, Sherry Carroll

Journal:

Year:

2003

Language:

english

File:

PDF, 155 KB

english, 2003

30

The Synthesis and Characterization of a Novel Insulin Sensitizing Agent

von Geldern, Thomas W., Brun, Regina P., Kalmanovich, Masha, Wilcox, Denise, Jacobson, Peer B.

Journal:

Year:

2004

Language:

english

File:

PDF, 85 KB

english, 2004

31

Amino-Substituted Heterocycles as Isosteres of trans-Cinnamides: Design and Synthesis of Heterocyclic Biaryl Sulfides as Potent Antagonists of LFA-1/ICAM-1 Binding.

Gary T. Wang, Sheldon Wang, Robert Gentles, Thomas Sowin, Sandra Leitza, Edward B. Reilly, Thomas W. von Geldern

Journal:

Year:

2005

File:

PDF, 17 KB

2005

32

Azole Endothelin Antagonists. 1. A Receptor Model Explains an Unusual Structure−Activity Profile

von Geldern, Thomas W., Hutchins, Charles, Kester, Jeffrey A., Wu-Wong, Jinshyun R., Chiou, William, Dixon, Douglas B., Opgenorth, Terry J.

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 334 KB

english, 1996

33

Design, Synthesis, and Activity of a Series of Pyrrolidine-3-carboxylic Acid-Based, Highly Specific, Orally Active ET B Antagonists Containing a Diphenylmethylamine Acetamide Side Chain

Liu, Gang, Kozmina, Natasha S., Winn, Martin, von Geldern, Thomas W., Chiou, William J., Dixon, Douglas B., Nguyen, Bach, Marsh, Kennan C., Opgenorth, Terry J.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 140 KB

english, 1999

34

Discovery of Novel p -Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intracellular Adhesion Molecule-1 Interaction. 1. Identification of an Additional Binding Pocket Based on an Anilino Diaryl Sulfide Lead

Liu, Gang, Link, J. T., Pei, Zhonghua, Reilly, Edward B., Leitza, Sandra, Nguyen, Bach, Marsh, Kennan C., Okasinski, Gregory F., von Geldern, Thomas W., Ormes, Mark, Fowler, Kerry, Gallatin, Mike

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 210 KB

english, 2000

35

A 32-year-old man with relapsing-progressive brainstem symptoms

Helmar C Lehmann, Ulrich R Hengge, Lutz Alswede, Andreas Saleh, Gloria von Geldern, Hans Peter Hartung, Thomas Ruzicka, Bernhard Hemmer

Journal:

The Lancet Neurology

Year:

2006

Language:

english

File:

PDF, 10.16 MB

english, 2006

36

“The next big thing” in diabetes: clinical progress on DPP-IV inhibitors

Thomas W. von Geldern, James M. Trevillyan

Journal:

Drug Development Research

Year:

2006

Language:

english

File:

PDF, 214 KB

english, 2006

37

Pyrrolidine-3-carboxylic Acids as Endothelin Antagonists. 5. Highly Selective, Potent, and Orally Active ET A Antagonists

Jae, Hwan-Soo, Winn, Martin, von Geldern, Thomas W., Sorensen, Bryan K., Chiou, William J., Nguyen, Bach, Marsh, Kennan C., Opgenorth, Terry J.

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 104 KB

english, 2001

38

Pyrrolidine-3-carboxylic Acids as Endothelin Antagonists. 2. Sulfonamide-Based ET A /ET B Mixed Antagonists

Jae, Hwan-Soo, Winn, Martin, Dixon, Douglas B., Marsh, Kennan C., Nguyen, Bach, Opgenorth, Terry J., von Geldern, Thomas W.

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 337 KB

english, 1997

39

Overview: The Atrial Peptide System as a Therapeutic Target

von Geldern, Thomas W

Journal:

Expert Opinion on Therapeutic Patents

Year:

1992

Language:

english

File:

PDF, 1.08 MB

english, 1992

40

Maturation of A71915-Dependent Inhibition of Atrial Natriuretic Peptide-Stimulated Cyclic GMP Production in Isolated Rat Glomeruli

Norling, Laura L., von Geldern, Thomas, Chevalier, Robert L.

Journal:

Year:

1994

Language:

english

File:

PDF, 1.07 MB

english, 1994

41

Preclinical development of an oral anti- Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis

Taylor, Mark J., von Geldern, Thomas W., Ford, Louise, Hübner, Marc P., Marsh, Kennan, Johnston, Kelly L., Sjoberg, Hanna T., Specht, Sabine, Pionnier, Nicolas, Tyrer, Hayley E., Clare, Rachel H., Coo

Journal:

Science Translational Medicine

Year:

2019

File:

PDF, 334 KB

2019

42

Discovery of ((4 R ,5 S )-5-Amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8 H )-yl)methanone (ABT-341), a Highly Potent, Selective, Orally Efficacious, and Safe Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

Pei, Zhonghua, Li, Xiaofeng, von Geldern, Thomas W., Madar, David J., Longenecker, Kenton, Yong, Hong, Lubben, Thomas H., Stewart, Kent D., Zinker, Bradley A., Backes, Bradley J., Judd, Andrew S., Mul

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 190 KB

english, 2006

43

Potent and selective inhibitors of an aspartyl protease-like endothelin converting enzyme identified in rat lung

Shiosaki, Kazumi, Tasker, Andrew S., Sullivan, Gerard M., Sorensen, Bryan K., von Geldern, Thomas W., Wu-Wong, Jinshyun R., Marselle, Carol A., Opgenorth, Terry J.

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 1.11 MB

english, 1993

44

Discovery of Novel p -Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intercellular Adhesion Molecule-1 Interaction. 4. Structure−Activity Relationship of Substituents on the Benzene Ring of the Cinnamide

Winn, Martin, Reilly, Edward B., Liu, Gang, Huth, Jeffrey R., Jae, Hwan-Soo, Freeman, Jennifer, Pei, Zhonghua, Xin, Zhili, Lynch, John, Kester, Jeff, von Geldern, Thomas W., Leitza, Sandra, DeVries, P

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 213 KB

english, 2001

45

‘Irreversible’ Endothelin-1 Binding Does Not Prohibit ABT-627 From Reversing Endothelin-1-Induced Effects

Chiou, William J., Wessale, Jerry L., Geldern, Thomas von, Opgenorth, Terry J., Wu-Wong, Jinshyun R.

Journal:

Journal of Cardiovascular Pharmacology

Year:

2000

Language:

english

File:

PDF, 67 KB

english, 2000

46

‘Irreversible’ Endothelin-1 Binding Does Not Prohibit ABT-627 From Reversing Endothelin-1-Induced Effects

Chiou, William J., Wessale, Jerry L., Geldern, Thomas von, Opgenorth, Terry J., Wu-Wong, Jinshyun R.

Journal:

Journal of Cardiovascular Pharmacology

Year:

2000

File:

PDF, 2.03 MB

2000

47

Liver-Selective Glucocorticoid Antagonists: A Novel Treatment for Type 2 Diabetes.

Thomas W von Geldern, et al. et al.

Journal:

Year:

2004

File:

PDF, 10 KB

2004

48

Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase

Chunqiu Lai, Rebecca J. Gum, Melissa Daly, Elizabeth H. Fry, Charles Hutchins, Celerino Abad-Zapatero, Thomas W. von Geldern

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 199 KB

english, 2006

49

Discovery of a potent atrial natriuretic peptide antagonist for ANPA receptors in the human neuroblastoma NB-OK-1 cell line

Christine Delporte, Jacques Winand, Piotr Poloczek, Thomas Von Geldern, Jean Christophe

Journal:

European Journal of Pharmacology

Year:

1992

Language:

english

File:

PDF, 786 KB

english, 1992

50

Discovery, Structure−Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors

Pei, Zhonghua, Li, Xiaofeng, Longenecker, Kenton, von Geldern, Thomas W., Wiedeman, Paul E., Lubben, Thomas H., Zinker, Bradley A., Stewart, Kent, Ballaron, Stephen J., Stashko, Michael A., Mika, Aman

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 409 KB

english, 2006

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